Akilan A., Senguttuvan S. and R. Poongodi
Abstract
A series of novel 2-aminoquinazolinol derivatives (5aâ5e) was synthesized from 4-aminoacetophenone and substituted aromatic aldehydes through ClaisenâSchmidt condensation, Michael addition, and subsequent cyclization with guanidine hydrochloride under reflux conditions to form the quinazolinone core. The synthesized compounds were purified and characterized by elemental analysis, FTIR, ¹H NMR, and ¹³C NMR spectroscopy. Their antimicrobial and antifungal activities were evaluated against selected bacterial and fungal strains using disc diffusion and serial dilution methods. The results indicate that substitution on the quinazolinone scaffold significantly influences biological activity, highlighting the potential of these derivatives for further medicinal applications.