Ecology, Environment and Conservation Paper


Vol. 32 (1), 2026

Page Number: 429-437

SYNTHESIS, CHARACTERIZATION, DFT ANALYSIS, AND BIOLOGICAL ACTIVITY OF CO(II) AND NI(II) COMPLEXES OF A NOVEL MANNICH BASE DERIVED FROM PHTHALIMIDE

G. Parthibarasu, M. Yosuva Suvaikin, C. Kalaivanan and S.S. Syed Abuthahir

Abstract

A biologically active new Mannich base was synthesised from phthalimide, benzaldehyde and dicyclohexylamine, known as dicyclohexylaminobenzylphthalimide (DBP). By using elemental analysis, FT-IR, UV-Vis, 1H-NMR, 13C-NMR, mass, electronic spectra, magnetic moment, molar conductance and TGA/DTA analysis, the structure of the Mannich base and its complexes has been clarified. Utilising the density functional theory (DFT) B3LYP/6-311G (d.p.) basic set, the chemical structure of the synthesized molecules was optimised. were carried out to assign the structure of newly synthesised compounds. The Co (II) and Ni (II) complexes MLX are given together with their general formula. The predicted HOMOLUMO gap offers interesting information on the intermolecular charge transfer reacting of the molecular system. The B3LYP method’s structural, vibrational, and electrical characteristics using the 6-311++G (d.p.) basic set. The agar-well method was used to test the antibacterial activity of the synthesised ligand and metal complexes against bacteria and fungal species. Compared to the ligand, the complexes are more active, and the complexes are more active.