G. Parthibarasu, M. Yosuva Suvaikin, C. Kalaivanan and S.S. Syed Abuthahir
Abstract
The new synthesis of Mannich base from nicotinamide derivative. The chemical structures of the Mannich base have been confirmed and elucidated by their physical and spectral data. The metal complexes of Nicotinamide containing Mannich base were synthesized and characterized by percentage of metal analysis, conductivity, FT-IR spectroscopy, UV-Vis spectroscopy and magnetic moment measurements. The molar conductivity of the complexes are much less than 54.0 Ã-1 cm2 mol-1 showed the non-electrolyte nature of the complexes. The IR spectra showed that the organic ligand is neutral bidentate bonding through the dicyclohexylamino ring nitrogen and one of the carbonyl oxygen nicotinamide moiety. The magnetic susceptibility data showed that all the complexes were paramagnetic. The general formula of the Co(II) and Cu(II) chloro complexes MLX2 are reported. The spectral analysis to ascertain mode of bonding and overall geometry of the complexes revealed square planner geometry. All the compounds synthesized were tested experimentally on their antibacterial activity against four Gram-positive and Two Gram-negative bacteria. The test outcomes revealed moderate to high antibacterial activity of metal complexes.