Ni Luh Made Rahayu Widya Lestari, Anak Agung Ketut Darmadi and Retno Kawuri
Abstract
Propionibacterium acnes bacteria can cause skin infections and usually treated with antibiotics, but most antibiotics are resistant and have toxic side effects on the body so alternatives are needed. One alternative to find new antibacterials from natural ingredients is to utilize cinnamon plants. This study aims to determine the ability of cinnamon leaf extract to inhibit the growth of P. acnes bacteria. Antibacterial activity testing was carried out on crude extract and an inhibitory power of 28.42mm was obtained with a very strong category. The inhibitory power test of cinnamon leaf extract was carried out using the well diffusion method using a Completely Randomized Design (CRD) with six concentration variations and four replications, and testing was carried out on clindamycin as a positive control and 70% ethanol as a negative control. In this study, concentrations of 0.75% and 1% had moderate inhibitory power and concentrations of 1.25%, 1.5%, 1.75% and 2% had strong inhibitory power. Based on the data analysis that has been carried out, cinnamon leaf extract has been proven effective in inhibiting P. acnes bacteria, the highest effectiveness was found at a concentration of 2%. The analysis of compounds with GC-MS, twenty-two types of secondary metabolite compounds were found and only four compounds had high concentrations namely geraniol, cinnamaldehyde, coumarin and hexadecanoid acid, methyl ester and six compounds with antibacterial activity namely eucalyptol, linalool, geraniol, cinnamaldehyde, coumarin and hexadecanoid acid, methyl ester. In the future this extract has potency as alternative medicine to combat the P.acne bacteria.