N.M.R. Suarni, N.G.A.M. Ermayanti, A.A.S.A. Sukmaningsih and A.M. Deshmukh
Abstract
The aim of this study was to find out the effects of ethanol extract of moringa leaf on liver histopathology white rats (Rattus norvegicus) induced by meloxicam. The experimental design used in this study was a Completely Randomized Design (CRD) with 5 treatments where K- was given only aquadest, K+ was given 8.4 mg/kg BW of meloxicam, P1 was given 8.4 mg/kgbw of meloxicam and 200 mg of moringa leaf extract, P2 was given 8.4mg/kg bw of meloxicam and 400 mg of moringa leaf extract and P3 was given 8.4 mg/kg BW of meloxicam and 600 mg of moringa leaf extract, and each treatment consisted of 5 replications. The treatment was carried out for 35 days. The parameters observed were hydropic degeneration, sinusoidal dilatation, venous congestion, fatty degeneration, necrosis, and inflammatory cell infiltration. The data obtained were analyzed by One Way ANOVA analysis and continued with Duncanââ¬â¢s test. The results showed a significant effect (P<0.05) of the ethanol extract of moringa leaves on liver histopathology white rats induced by meloxicam. It can be concluded that the ethanol extract of moringa leaves in this study can prevent liver cell damage in white rat caused by meloxicam.