CHANGING PATTERN OF ANTIMICROBIAL SUSCEPTIBILITY OF HELICOBACTER PYLORI IN PATIENTS WITH ACID PEPTIC DISEASESG. SHANTHI , JOSEPH PUSHPA INNOCENT AND S. SELVAKUMAR
Alarming rate of increasing resistance of H.pylori isolates to various anti-bacterial agents suggest that the antibiotic susceptibility tests should be performed to assess the changing pattern of antimicrobial susceptibility of H. pylori isolated from patients with acid peptic diseases. Antralbiopsy were collected from patients with gastritis, duodenal ulcer, non-ulcer dyspepsia (NUD) and gastric carcinoma, from the patients undergoing endoscopic procedure at University Hospital Annamalainagar. All the biopsy specimens were processed for H. pylori histology, Grams stain, urease test and culture. All positive cultures were tested for its antibiotic susceptibility to metronidazole, clarithromycin, amoxyciline, tetracycline, ciprofloxacin, co-amoxiclav and levoflaxacin, minimum inhibitory concentration were determined and the pattern of susceptibility were analysed using disk diffusion technique. Among 110 H. pylori isolates 68% were resistant to metronidazole, 53% to amoxicillin, 24% of clarithromycin 20% ciprofloxacin and 12% to tetracycline. None of the patients were found resistance to co-amoxiclav and levoflaxacin. Results suggested that the antimicrobial susceptibility test should be performed prior to the treatment of H. pylori infection to achieve better results and to reduce the risk of H. pylori resistant strains.
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