ROLE OF VITAMINS ON LEAD ACETATE INDUCED ESTROUS CYCLICITY IN SWISS MICEN. QURESHI, R. SHARMA, R. BANU AND S. MOGRA
Lead compounds are known to induce toxicity in mammalian systems. However, reproductive toxicity is comparatively less expediated. We have investigated reproductive toxicity of lead given orally as a daily dose of 160 mg/kg body weight and 320 mg/kg body weight for 30 days. Along with this, the therapeutic effect of ascorbic acid and alpha-tocopherol on lead induced toxicity has also been investigated. In low as will as high dose treated groups, females showed irregular cyclicity with predominate diestrous stage and the numbers of estrous cycles were also reduced in one month period. Supplementation of ascorbic acid and alpha-tocopherol reduces the toxic effects and females exhibit regular cyclicity and the number of estrous cycles also increased towards normal number. The treatment with only ascorbic acid and alpha-tocopherol, exhibited no alterations in the number of estrous cycle and there was no effect on the cyclicity. This study suggests that the two vitamins (C&E) should be taken in combination for beneficial and desirable effects in lead poisoning.
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