Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 10, Issue 4, 2008; Page No.(817-820 )

ANTI-ULCER EFFECT OF COLDENIA PROCUMBENS L. AGAINST GASTRIC ULCER

S. NETHAJI, N. THAJUDDIN AND C. MANOHARAN

Abstract

he ethanolic extract of Coldenia procumbens leaf and root were evaluated for its anti-ulcer activity against pylorus ligation induced gastric ulcer (antisecretory) in albino rats. We found that C. procumbens extract at a dose of 100 mg/kg p.o. markedly decrease the incidence of ulcers. Both leaf and root extracts of C. procumbens showed significant reduction in gastric volume, free and total acidity and ulcer index. The plant extracts possess significant gastro protective activity as compared with standard drug.

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