A MECHANISM FOR THE CONVERSION OF OXYHEMOGLOBIN TO METHEMOGLOBIN BY POTASSIUM FERRICYANIDEDILIP B. PATIL AND PRAKASH R. KAKDE
The kinetics of oxidation of oxyhemoglobin by potassium ferricyanide has been investigated spectrophotometrically. The reaction has been shown to be second order with specific reaction rate of 2.36 x 1021VI1s-1 at pH 6.00 and temperature 25.0°C. The energy of activation, frequency factor and entropy of activation are found to be 21.42 kl Mo1e-1, 1.34 x 10' and -135.89 JK-'mol-' respectively. The specific reaction rate is influenced by hydrogen ion concentration (pH) and saline concentration. The most likely mechanism has been suggested.
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