DEGRADATION OF AFLATOXIN B1 USING THE HERBAL DRUG, LIV-52VISENUO AIKO AND ALKA MEHTA
The objective of this study was to determine the potential of the herbal drug, Liv-52, and its components in degrading aflatoxin B1 (AFB1). Degradation was carried out by incubating AFB1 with various concentrations of Liv-52 and its components at 37 °C for 24 and 48 h. The inhibitory effect of Liv-52 on growth of Aspergillus flavus and AFB1 production in yeast extract sucrose medium was studied. Liv-52 showed efficiency in degrading AFB1, which increased with increasing concentration of the drug. Incubation of AFB1 with 100 mg/mL of Liv-52 resulted in 50% degradation; however complete degradation was not obtained. Among the constituents of Liv-52, Tamarix gallica and Terminalia arjuna were most effective in degrading AFB1, whereas Cichonium intybus and Solanum nigrum did not exhibit any degradation effect. The drug did not exhibit any inhibitory effect at the concentrations used. On the contrary, the presence of Liv- 52 in culture medium had enhanced the growth of A. flavus and AFB1 production. The results showed that Liv-52 could serve as a protective agent against AFB1, which is hepatotoxic.
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