PRESENCE OF MANNOSE BINDING LECTIN ON DENGUE INFECTIONR. AMELIA, Y.P. DACHLAN, R. PUSPITANINGRUM3 AND A.B. SUSANTO
Dengue Hemorhagic Fever (DHF) is endemic in Indonesia. DHF is caused by Dengue virus (DENV) as a result of the bite of the mosquito Aedes aegypti. Responses innate immune are activated in DENV infection. Mannose binding lectin (MBL) protein plays a role in the activation of the lectin pathway of complement so that the protein acts as a Pattern Recognition Receptor for dengue virus envelop. In this study we wish to understand the relationship between the concentration of MBL with clinical degree of dengue infection. The study was conducted with a cross-sectional method. In all 64 dengue patients in hospital Cipto Mangunkusomo and Cijantung, Jakarta in May-October 2014 were studied. The results of this study showed degree of DHF has a weak relationship for MBL. Calculations with multivariate regression analysis on degree of DHF with mannose binding lectin protein, gender, age, platelets, hematocrit, and infection of primary/secondary obtained a very strong correlation. The results of this study demonstrate that MBL protein has a weak relationship for degree of DHF and MBL levels in pediatric patients infected with dengue acute phase more than the adult group. We assume MBL binds to the platelet cell membrane thereby activating the lectin pathway of complement system that cause thrombocytopenia.
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