ANTIBIOTIC RESISTANCE PROFILE OF METHICILLIN SUSCEPTIBLE AND RESISTANT STAPHYLOCOCCUS AUREUS ISOLATED FROM PATIENTS AT ALJOUF AREA, SAUDI ARABIAOMER MOHAMED KHALILAbstract In order to have adequate information for treatment of methicillin susceptible S. aureus (MSSA) and methicillin resistant S.aureus (MRSA) infections, it is crucial to understand the trends in the antibiotic-resistance patterns. The present study aimed to examine the antibiotic resistance profile of MSSA and MRSA isolated from patients at Aljouf area. In this study, multiple antibiotic resistance profiles against thirteen antibiotics were investigated for 84 MSSA and 61MRSA clinical isolates obtained from three hospitals in Aljouf area, Saudi Arabia. Isolates were identified and susceptibility testing was carried out using semi-automated Vitek2 compact system. Polymerase chain reaction (PCR) was used to confirm the identification of MRSA strains. All isolates of MRSA were completely resistant to Penicillin, oxacillin and ampicillin, while oxacillin, and vancomycin were completely sensitive to MSSA. Other antibiotics which were more than 90 % sensitive to MSSA include teicoplanin, Linozolin, moxifloxacin, ciprofloxacin and cotrimoxazole. Resistant of MRSA to teicoplanin, linozolinm, oxifloxacin and corrimoxazole were 7%, 10%, 20% and 60 % respectively. Only 57 (94%) of the MRSA isolates expressed megA gene in the PCR product. Our data suggests the monitoring of emerging resistance profiles in this area to maintain treatment efficacy to resistant pathogens.
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