PHYTOCHEMICAL AND ANTIMICROBIAL ACTIVITY OF DOLICHANDRONE FALCATA STEM ON SOME DRUG RESISTANCE BACTERIAL SPECIESA.S. BAGWAN AND M.E. KISHORE
The present study aims to evaluate the possibility for the presence of novel bio-active compounds against pathogenic bacteria, as most of the pathogens develop drug resistance against commonly used antibiotics. To determine antibacterial activity, stem extract of Dolichandrone falcata (vernacular name: Medhshingi) was tested against bacterial species of clinical significance. The stem extract shows very promising result. The aqueous, acetone and ethanol extracts of plant stem was prepared and evaluated for its phytochemical properties and antimicrobial activities. The phytochemical analysis of the preparation revealed the presence of some secondary metabolites which includes: tannins, flavanoids, glycosides, steroids, saponins and alkaloids. The In vitro antimicrobial activity of the crude aqueous, acetone and ethanol extract of the Dolichandrone falcata were investigated. The extract showed antimicrobial activities against the test organisms with different zones of inhibition. The minimum inhibitory concentration (MIC) of the acetone extract was between 10- 20 mg/mL. The ability of the crude extracts of Dolichandrone falcata to inhibit the growth of microbes is an indication of its antimicrobial potential, which may be employed in management of microbial infections.
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