Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 11, Issue 4, 2009; Page No.(943-946)

IMMUNOSUPRESSIVE EFFECT OF SEVINŽ ON THE HUMORAL IMMUNE RESPONSE TO PROTEIN AND CELLULAR ANTIGENS IN OREOCHROMIS MOSSAMBICUS (PETERS)

E. JOY SHARMILA AND S.K. DWARAKANATH

Abstract

The indiscriminate use of chemicals has caused concern about the toxic effects of the residues on non-target organisms. The carbamate pesticide which contains carabaryl, is widely used against sucking pests. The purpose of this study was to determine the effect of different concentrations of Sevin, a pesticide that contains carbamate, on the humoral immune response to three antigens S-BSA(Soluble Bovine Serum Albumin), HA-BSA( Heat Aggregated Bovine Serum Albumin) and SRBC(Sheep Blood Cells). The antibody response was studied by passive heamagglutination assay. The fish after challenged with the antigens showed decrease in antibody response to Sevin at all doses. The degree of supression showed a positive correlation to the concentrations of the pesticide and dose dependent immunosuppression was noticed.

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