Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 9, Issue 1, 2007; Page No.(211-214)

PREDICTION OF ANTICARCIN °GENIC POTENTIAL OF GARLIC BY IN VITRO RA T LIVER MICROSONIAL DEGRANULATION

MONICA SOOD, GULREZ, AMA RJIT SINGH, H.M. DAN! AND RAJESHWAR SHARMA

Abstract

In vitro rat hepatic microsomal ciegranulation is one of the short term techniques that has been employed for the detection of potential chemical carcinogens. This technique measures the knocked-off ribosomes from microsomal membranes by the electrophilic moieties emanating from the activated carcinogens by monitoring the reduction in the RNA/ protein ratios. The present study has been carried out to study the inhibition of ribosome- membrane disruption against the 4-climethyl aminoazobenzene(4- DAB), Benzidine, b-Napthylamine and 9,10-Dimethyl 1,2 Benzanthracene (DBA) as the degranulating agents by measuring the RNA/protein ratios of microsomal membranes in the presnce or absence of garlic preparations. Our results show that microsomal degranulation technique besides its use to detect the chemical carcinogens, may also be successfully employed as a rapid tool to detect the anticarcinogenic potential of dietary components like garlic. There has been growing interest in finclinp- cliptarv

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