ANTIDIABETIC ACTIVITY OF CATHARANTHUS ROSEUS IN ALLOXAN INDUCED DIABETICS RATSM. MEENA AND K. PASUPATHY
The hypoglycemic activity of Catharanthus roseus is tested in Alloxan induced Diabetic rats. Single dose of alloxan monohydrate solution injected intramuscularly produce persistent hyperglycemia after 24 hours and served as control Diabetic (Group II). Treatment groups are divided into two one receiving Catharanthus roseus leaf powder 4mg and 8mg, which are dissolved in 2m1 of distilled water and orally administered for 6 days. Animals treated with Alloxan showed significant increase in blood glucose level (p<0.01) and a sharp decline in the liver glycogen level. In treatment group III (4 mg), there is significant reduction in blood glucose and improvement in liver glycogen level.'In treatment group IV (8 mg), the blood glucose level almost returns to normal level and showed improvement in glycogen level also. The levels of SGOT, SGPT, urea and cholesterol also restored to normal in treatment groups.
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