UNFOLDING THE INFLUENCE OF ENVIRONMENTAL FACTORS ON THE MATURATION OF POLYCYSTIC OVARIAN SYNDROMESRIPARNA DE, GOPESWAR MUKHERJEE, ARPITA ADHIKARI, SHREYA DAS, RAJKUMARI DEEPIKA AND ANIMESH DEYAbstract In this review we highlight the detrimental effect of numerous environmental factors potentially implicated in the etiology, prevalence and inflection of polycystic ovarian syndrome (PCOS) in woman population. PCOS is a heterogeneous multifaceted disease of woman emanating infertility, abnormal fetal growth and irregular menstruation. Precisely, the leading environmental factors we discuss include oxidative stress, environmental toxins, lifestyle, nutrition and heavy metal elements causing the onset of PCOS. Research evidences explore that environmental toxins can potentially induce the oxidative stress through (reactive oxygen species) ROS generation, thereby disrupting the reproductive health system. Additionally the synergistic influence of certain dietary supplements and weight loss in obese women has also deliberated. The features of key nutritional factors in preventing or mitigating the growth of PCOS as well as its associated with other metabolic disorder have scrutinized. Finally, further research in these avenues is highly admirable since global scenario of PCOS is remarkably crucial pointer of socioeconomic, environmental and epigenetic factors that possibly leads to adverse health effects in future generations of the world. |