PROTECTIVE ROLE OF RESVERATROL AGAINST OXIDATIVESTRESS INDUCED BY ALUMINIUM AND FLUORIDE IN RAT BRAINN. CHANDRA SHAKAR REDDY AND K. PRATAP REDDYAbstract Aluminium and Fluoride, known to form a strong complex, are being used widely in many industries. Both elements are involved in the pathogenesis of neurodegenerative disorders by inducing oxidative stress. Many experimental studies reported neuroprotective properties of resveratrol (Res). In this study, we examined the ameliorative effects of resveratrol on aluminiumfluoride-induced oxidative stress in the conventional and preclinical models. AlCl3 (100 mg/kg bw)+ NaF (10 mg/kg bw), AlCl3 (100 mg/kg bw) + NaF (10 mg/kg bw) + Res (30 mg/kg bw), and Res (30mg/kg bw) were administered for II, III and IV groups respectively and group-I was served as control for 8 weeks. The results showed considerable (p<0.05) alterations in protein content andoxidative markers (GPx, GST, GR, GSSH) in group-II whereas a significant (p<0.05) reversal was observed in group III. Taken together, the above findings indicate that resveratrol significantly alleviated the aluminium and fluoride-induced oxidative stress through its ameliorative efficacy. |