FORMULATION AND EVALUATION OF GRANUL EFFERVESCENT OF CATECHIN FROM GAMBIER (UNCARIA GAMBIER (HUNTER) ROXB)Henni Rosaini, Yoky Elfadri, Indra Makmur, Wahyu Margi Sidoretno, Auzal Halim and Rina Desni YettiAbstract Extract of Gambier (Uncaria gambir (Hunter) Roxb) contains catechin compounds with antioxidant, antimicrobial, and antihelminthic activities. This study aims to determine whether the catechin gambier can be formulated as a foamy granule preparation and know whether the evaluation of the quality of the effervescent granules meets the criteria for suitable granules. The effervescent granule formula was made by the wet granulation method with two procedures with different levels of active substances. In formula 1 (F1), the level of catechins is 12%. In formula 2 (F2), the levels of catechins are 8%. Although effervescent granule evaluation tests such as compressibility test, flow rate, angle of repose, pH, and dispersion time, F1 and F2 meet the criteria of effervescent granules, testing the water content of the effervescent granules in F1 and F2 did not meet the suitable measures. |