ECO-FRIENDLY SYNTHESIS OF BIOLOGICALLY ACTIVE SPIRO HETEROCYCLESShailendra Yadav and Sushma Singh
In the present synthesis work, some heterocyclic compounds1,2,3,4, and their derivatives were synthesized by environment benign mechanical grinding assistance or mechanochemical method and as well as conventional methods without assistance of grinding. Structures of synthesized compounds were determined by Elemental analysis, I.R., and NMR spectral data. All synthesized compound were evaluated for their insecticidal and fungicidal activities in which compound 3&4 exhibited better results. It was observed that mechanochemical method gave not only better results but also utilized less quantity of solvent and energy than conventional methods.