THERAPEUTIC EFFECT OF CURCUMIN DERIVATIVES/ANALOGUES OF INDIAN SPICE TURMERICANJALI, UDAYA PRATAP SINGH, RUBINA LAWRENCE AND EBENEZER JEYAKUMARAbstract Curcumin (CU), an edible natural pigment from the rhizome of Curcuma longa, (Turmeric) has demonstrated extensive anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic and anti-cancer activity in vivo and in vitro. With the physicochemical features of reversing low solubility, less bio accessibility and poor stability, CU structure has to be modified chemically through substituting functional ailments or to develop the CU hybrids. However, the poor stability, solubility, in vivo bioavailability and weak activity of CU greatly limit its therapeutic applications. Therefore, modified CU analogues have been extensively studied to determine the variety of biological and pharmacological activities, providing protection against infectious agents and chronic diseases. Starting from the study of natural CU analogues, multiple approaches are being sought to obtain more stable, soluble and effective analogues of CU. This review also displayed the bioactivity of Curcumin and its analogues in combination of with other biologically active compounds and describe the most recent and potent analogues against the infectious agents and chronic disorders. |