GREEN TEA LEAVES EXTRACT EFFECT ON HISTOPATHOLOGY OF MERCURY CHLORIDE INDUCED RAT’S LIVERRENADA GEMA HIMAWAN, HARDANY PRIMARIZKY, MASLICHAH MAFRUCHATI, NUSDIANTO TRIAKOSO, WIDJIATI, LILIK MASLACHAH AND ARIMBIAbstract This research was aim to observe the histopathology of mercury chloride induced rat's liver given green tea extract in different dosages. Thirty rats were divided into five groups with different treatments and administered through orally for 20 days. The treatment consist of negative control (CMC Na 1% solution + aquadest), positive control (CMC Na 1% solution + 8 mg/kg bw of mercury chloride), treatment 1, 2 and 3 (200, 400, and 800 mg/kg bw of green tea leaves extract respectively + 8 mg/kg bw of mercuric chloride). Scoring data was analyzed by Kruskal Wallis and continued with Mann-Whitney U test to see the significant difference (p<0.05) between all treatments. Result analysis is there are a significant difference between negative control and positive control that indicate mercuric chloride significantly decreased the necrosis and degeneration of liver cells and treatment 3 (800 mg/kg bw) gave the best prevention for histopathology necrosis and degeneration of liver cells. The conclusion is green tea leaves extract could protect rats liver from the damage effect of mercuric chloride. This research aimed to prove the preventive effect of green tea leaves extract (Camellia sinensis) on rats (Rattus norvegicus) that are induced by mercuric chloride. |