CRUSHING COMPARED TO SIMPLE SUSPENSION METHOD IN PREPARING OF SPIRONOLACTONE TABLET SUSPENSIONYARDI SAIBI, NELLY SURYANI AND SILVIA ARYANIAbstract In the case of patients cannot take the medicine in the form of solid dosage form such as tablet and capsule, the drug has to be prepared in the solution before administration. Crushing the tablet is common method to be used in Indonesian hospital setting. Simple suspension method is recently used and developed in Japan. The objective of this research was to compare the two suspension in preparing spironolactone tablet. Spironolactone tablet was used based on the hospital case. The percentage of spironolactone concentrations of both suspension methods were measured by using High Performance Liquid Chromatography (HPLC) based on methods of United State Pharmacopeia. The test was conducted by sampling at 0, 15, 30, 45, and 60 minutes. The results showed that there was a change of spironolactone contents in both of methods. In crushing suspension method, the spironolactone content was 93.95% at 5 minute and decreased to - 89.23% after 60 minutes. Simple suspension method gives better results, i.e. 97.27% to 95.15%. Simple suspension method is better suspension method to be used because it can maintain spironolactone contents as monographic requirements which is 95% - 105%. |