Vivek Chopra, Rajesh Kumar, Meenam Bhatia, Puneet Bansal, Gouri, Priyanshi, Yukti Kasodniya, Priyanka Panwar, Nayan Chakraborty, Abhishek Bhatt, Prerna Kumari, Anupriya, Shafaque Shamim, Kavya Shree, Sukaran Malhotra, Tarun Rawat, Sukanya, Amrita and Indr
Abstract
Established in 1988, the National Center for Biotechnology Information (NCBI), part of the U.S. National Library of Medicine (NLM) and the National Institutes of Health (NIH), was created to advance resources and tools that support biomedical and genomic research. This paper outlines the main databases and digital tools maintained by NCBI, focusing on their structure, function, and significance in the life sciences and biomedical sciences. Its vast array of resources can be categorized into six key domains: scientific literature, nucleotide and genome sequences, protein and structural data, gene expression and epigenetic profiles, genetic variation and phenotype information, and computational and chemical analysis tools. Since taking over the management of GenBank in 1992, NCBI has worked in close coordination with global partners such as the European Molecular Biology Laboratory (EMBL) and the DNA Data Bank of Japan (DDBJ) to curate and share sequence data. These resources help researchers across the world in retrieving biomedical literature, exploring molecular structures and identifying genetic variants. By integrating vast datasets with genomics, proteomics, and transcriptomics, researchers can conduct advanced studies. The present study provides a compilation of the data, tools, and resources available on NCBI and their applications across various forms of biological sciences.