ANTIMICROBIAL PROFILE INVESTIGATION OF NOVEL PROSPECTIVE ULTRA-SHORT ACTING ANTAGONISTS OF β-ADRENERGIC RECEPTORSPETR MOKRÝ JOZEF CSÖLLEI, IVAN MALÍK, MARIÁN BUKOVSKÝ AND EVA SEDLÁROVÁ
Due to worldwide phenomenon of microbial resistance to commonly used therapeutic agents, antibiotics and antifungals as well, a non-traditional series of perspective ultra-short acting β-adrenoceptor blockers, labelled as 1Â–4, has been in vitro evaluated against selected Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial strains as well as against yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. From chemical viewpoint, the presence of polar carboxy group within the structure of tested compounds has not found to be favourable structural feature because of its supposed splitting by the enzymes which have been produced by all concerned microorganisms. On the other hand, within inspected set of the compounds, the increase in the lipophilicity has meant moderate improvement of the effectiveness against S. aureus and C. albicans, reaching the maximum for the most lipophilic substance 4 which has shown MIC=0.78 mgÂ·mL-1 for given bacteria and yeast as well.
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