THE EFFECTIVENESS OF CINNAMOMUM (CINNAMOMUM BURMANNII) ESSENTIAL OIL ON THE REDUCTION OF INFLAMATION LEVELS IN WHITE RAT LIVERS (RATTUS NORVEGICUS) INDUCED BY STREPTOZOTOCINAgus Arisma, Mohammad Sukmanadi, Hani Plumeriastuti, Mustofa Helmi Effendi, Budiastuti and Sheila Marty Yanestria
The purpose of this study was to determine the effectiveness of administration of cinnamon (Cinnamomum burmannii) essential oil on hemorrhage, congestion, and inflammatory cell infiltration in the liver of white rats (Rattus norvegicus) induced by streptozotocin to make artificial Diabetes Mellitus (DM). Thirty adult male rats, aged 2-4 months, weighing 130-140 g were divided into six groups. K (-) control group was given drug solvent, K (+) DM rats were given drug solvent, P1 group DM rats were given glibenclamide 0.45 mg / Kg BW + drug solvent, P2, P3, P4 were group of DM rats given oil therapy Cinnamon volatile with doses of 100mg/kg BW, 200mg/kg BW, and 400mg/kg BW, respectively. Therapy was given orally for 14 days. At the end of the study, all experimental animals were euthanized and their livers were taken. The liver was made histopathological preparations with Hematoxylin eosin staining and calculated bleeding, congestion, and inflammatory cell infiltration. The results showed that the lowest number of hemorrhage, congestion, and inflammatory cell infiltration was in the negative control group (K-), the highest number in the positive control group (K+), and the lowest in the treatment group was P3. The results showed a decrease, but no significant difference in hemorrhage. There are significant differences in inflammatory cell congestion and infiltration. The results of this study concluded that cinnamon essential oil can reduce the level of inflammation.