ANTIMICROBIAL POTENTIAL OF STREPTOMYCES ALBOGRISEOLOUS VJMS-7 ISOLATED FROM COASTAL REGIONS OF GUNTUR DISTRICT, ANDHRA PRADESH, INDIAMARY SWAPNA MOGILI AND VIJAYALAKSHMI MUVVA
The aim of the present study is to isolate and identify promising antimicrobial metabolite producing actinomycetes from the coastal regions of Guntur district, Andhra Pradesh, India. The soil samples collected were pre-treated with calcium carbonate, diluted and plated on yeast extract malt extract and dextrose (YMD) agar medium to isolate actinomycetes. All the isolates were screened for antimicrobial activity. Among the fifty isolates screened, one isolate designated as VJMS-7 exhibited high antimicrobial potential. The isolate was identified by studying the micro-morphological, cultural, biochemical, physiological and molecular methods. The potential isolate was identified as Streptomyces albogriseolous VJMS-7. The growth pattern of the isolate was studied by culturing it in YMD broth. The culture broth was extracted with ethyl acetate and the solvent extract was tested for antimicrobial activity. It inhibited Grampositive bacteria as well as Gram-negative bacteria and fungi. As the extract of S. albogriseolous VJMS-7 showed significant antimicrobial activity, it may be used for finding the new clinically useful compounds.
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