Ecology, Environment and Conservation Paper

Vol 25, Issue 3 2019; Page No.(1416-1423)

THE EFFECT OF JATROPHA CURCAS L. SEED EXTRACT IN APOPTOSIS OF HEPAR TISSUES

E. Wulandari, R.A.F. Hapsari, T. Bayyina and N.A. Hasanuddin

Abstract

Tumor or neoplasm, mutation can cause an increased the mass of abnormal tissue and grows excessively. It is not coordinated and grow continuously even though the stimuli was stop. Nowadays many people die due to tumors, it is a form of paramedics’ failure. One of the methode to suppress the tumor, by using Jatropha plants (Jatropha curcas L) that known to be anti-tumor. To understand the character of these plants, we are doing a research to know is the molecular mechanisms in apoptosis (programmed cell death). Protein which plays in an important role in stimulating apoptosis are p53 (upstream) and caspase-3 (downstream). Therefore, the purpose of this study was to know the effect of Jatropha seed (Jatropha curcas L) on the apoptosis mechanisms. The jatropha extract has increased of apoptosis in hepar tissues and cause damage to the hepatocyte.

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