SCREENING OF ANTIBACTERIAL ACTIVITY FROM ASPERGILLUS SPECIES TREATED WITH SYNTHETIC ANTIFUNGAL AGENTMARWAN Y. AL-MAQTOOFI, AHMED A. BURGHAL AND ADNAN A. AL-MUOSAWI
The raising level of multi-resistant bacteria to antibiotics motivate the efforts over the countries to search for novel antibacterial source. Our study focused on preliminary screening for the antagonistic activity of four Aspergillus species belong to A. niger, A. flavus, A. fumigates, and A. terreus that chemically treated with antifungal chloro-traizine comparing with untreated (wild type) isolates against selected Gram positive and negative pathogenic bacterial strains including Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Proteus sp., Klebsiella pneumoniae, and Pseudomonas aeruginosa. The antibacterial activity of Aspergillus species was varying based on the strain, and the tested bacteria. All the chemically treated and untreated Aspergillus sp. revealed high antibacterial activity against Bacillus subtilis, and S. aureus. Chemically treated A. niger was the only strain supress efficiently the growth of E. coli. In contrast, untreated A. niger, A. flavus and A. fumigatus inhibit the growth of Proteus sp. higher than the treated strains based on the zone of inhibition. Untreated A. niger reveals high antibacterial activity on K. pneumoniae in comparison with other untreated Aspergillus strains. P. aeruginosa exhibited notable resistance for treated and untreated Aspergillus strains. In conclusion, chemically treated Aspergillus species can be used effectively for production of a novel antibacterial compound that supress the growth of some common pathogens.
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