MICROBIAL TRANSFORMATION OF THE ANTIMALARIAL AND ANTICANCER DRUG ARTEMISININ BY WHITE-ROT BASIDIOMYCETESI.A. PARSHIKOV, C.E. HERNANDEZ-LUNA AND E.I. ZARAISKY
We studied transformation of the potential anticancer drug artemisinin by the white-rot basidiomycetes Pycnoporus sanguineus and Funalia trogii. The fungi were grown on sucrose-malt broth in the presence of artemisinin for 14 days. Transformation products were extracted with ethyl acetate and analyzed by HPLC. Each of the fungi produced only a single metabolite from artemisinin. Products of transformation were identified by mass spectrometry and NMR methods. 5β-Hydroxyartemisinin was isolated from the incubation medium of P. sanguineus in 92.1% yield and 7β-hydroxyartemisinin was isolated from the incubation medium of F. trogii in 89.7% yield.
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