Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 20, Oct Suppl. Issue, 2018; Page No.(208-213)

IDENTIFICATION OF TGF1 RECEPTOR EXPRESSION IN ABNORMAL OVARY: THE CASE OF OVARIAN HYPOFUNCTION

NURUL ISNAINI, YUDIT OKTANELLA AND HERAWATI

Abstract

This study examined the expression of TGFb type 1 receptor (TGFR1) of Peranakan Ettawah (PE) goat ovarian follicles undergo ovarian hypofunction. To evaluate the TGFR1, ovaries were recovered from 30 goat ovaries collected from abattoir, later be observed and divided into three groups (Group1: hypofunctional ovary; Group2: normal ovary in luteal phase; Group3: normal ovary in follicular phase) based on the ovary performance macroscopically. Immunohistochemistry was performed to identify the TGFR1 receptor expression in atretic, secondary and tertiary follicles from the groups. Our results showed that the number of TGFR1 expression of atretic and granulosa cells from ovarian hypo function was higher than normal ovary. Based on these results, TGFR1is essential for the regulation of caprine follicular development in ovarian hypofunction. It’sover expression in ovarian hypo function could be related to apoptotic condition, which was also correlated to atretic follicle number in ovarian hypo function in vitro. This finding suggests that the difference expression’s patterns of TGFR1 in normal folicullar and lutheal also hypofunction ovary is related to its function in folliculogenesis in PE goat. Future studies are necessary to identify the correlation of TGFR1in maturation rates of oocytes since it’s been expressed almost on all stages of developing follicles.

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