IDENTIFICATION OF TGF1 RECEPTOR EXPRESSION IN ABNORMAL OVARY: THE CASE OF OVARIAN HYPOFUNCTIONNURUL ISNAINI, YUDIT OKTANELLA AND HERAWATI
This study examined the expression of TGFb type 1 receptor (TGFR1) of Peranakan Ettawah (PE) goat ovarian follicles undergo ovarian hypofunction. To evaluate the TGFR1, ovaries were recovered from 30 goat ovaries collected from abattoir, later be observed and divided into three groups (Group1: hypofunctional ovary; Group2: normal ovary in luteal phase; Group3: normal ovary in follicular phase) based on the ovary performance macroscopically. Immunohistochemistry was performed to identify the TGFR1 receptor expression in atretic, secondary and tertiary follicles from the groups. Our results showed that the number of TGFR1 expression of atretic and granulosa cells from ovarian hypo function was higher than normal ovary. Based on these results, TGFR1is essential for the regulation of caprine follicular development in ovarian hypofunction. Itsover expression in ovarian hypo function could be related to apoptotic condition, which was also correlated to atretic follicle number in ovarian hypo function in vitro. This finding suggests that the difference expressions patterns of TGFR1 in normal folicullar and lutheal also hypofunction ovary is related to its function in folliculogenesis in PE goat. Future studies are necessary to identify the correlation of TGFR1in maturation rates of oocytes since its been expressed almost on all stages of developing follicles.
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