Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 20, Issue 1, 2018; Page No.(108-112)

POTENTIALITY OF EXTRACTED PAPUA’S ANTHILL (MYRMECODIA PENDANS) AS ANTITUMOR TO EMPHASIZE THE EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN CELL BURKITT’S LYMPHOMA CANCER

HARUN ACHMAD, PUTRI KHAIRUNNISA, MARDIANA AND AZIMAH KARNI AULIYA

Abstract

To know the effectiveness of antitumor extracts of Papua ant nest (Myrmecodia pendans) through angiogenesis barrier (suppression of VEGF expression) on cell culture of Burkitt's lymphoma. This was a purely laboratory experimental study using Burkitt's lymphoma cell culture as the sample. This study consists of several stages of identification of ant nest plants, cytotoxicity test extract on Burkitt's lymphoma cell culture, and angiogenesis barrier test. This research uses mixed method, namely descriptive explorative during the first step and experimental laboratory in the second stage. Obtained the value of Raji cell death presentations of 92.46% at the concentration of 500 μL extract and from the calculation of linear regression obtained that the IC50 test extract value is 25.88 ppm. The most significant decrease in VEGF expression was seen in the treatment group of IC50 extract (I), i.e. from 24 hours to 72 hours incubation ie 266.04 pg/mL. Ant nest extract (Myrmecodia pendans) is able to inhibit angiogenesis through suppression of VEGF expression of Burkitt's lymphoma cancer cells.

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