Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol.12, Issue 1, 2010; Page No.(49-53)

ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC PROPERTY OF SMILAX CHINA IN ALLOXAN INDUCED DIABETIC RATS

U. SARASWATHI AND N.R. NITHYA

Abstract

The present study was performed to analyse the effect of hydroethanolic extract of Smilax china for antihyperglycemic and antihyperlipidemic property in alloxan-induced diabetic rats. Alloxan was administered as a single dose (150 mg/kg body weight) to induce diabetes in male Wistar rats and the plant extract was administered for 4 weeks at a dose of 500 mg/kg body weight. At the end of 30 days, concentration of blood glucose, serum insulin, serum urea, serum creatinine, serum marker enzymes, serum cholesterol, serum triglycerides and liver glycogen were estimated. Alloxan treatment significantly (P<0.05) elevated the levels of blood glucose, serum urea, creatinine, cholesterol, triglycerides, AST, ALT and LDH. In contrast, serum insulin, amylase and liver glycogen were significantly reduced in diabetic control. Oral administration of Smilax china extract for 30 days reverted the biochemical parameters to near normal. This investigation suggests the hypoglycemic and hypolipidemic property of Smilax china and could be useful for the treatment of diabetes.

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