AZETIDINONE (ß-LACTAM) DERIVATIVES : AN EMERGING ANTIMICROBIALSY. ROKADE, N. DONGRE, G. ENGLA, C. BEHERA AND R. SAYYED
The discovery development and identification of biologically active compounds has gain lot of importance in the recent years, even though there is considerable number of dreadful and fatal adverse effect, the medicinal chemists have always tried to design drug substance possessing maximum therapeutic application and minimum toxicity .combinatorial synthesis has brought a lot of evaluation in the recent trends of drug synthesis. Azetidine derivatives (ÃŸ-lactam) containing nitrogen (N) have been identified as new range of potent antimicrobials effective against wide range of pathogens. They occupy a central place among medically important compounds due to their diverse and interesting antibiotic properties. Large number of 3-chloro monocyclic ÃŸ-lactams having substitution at position 1 and 4 posses powerful antimicrobial, sedative and anti-tubercular activity. All ÃŸ-lactam antibiotics interfere with the synthesis of bacterial cell wall and the cell wall deficient forms are osmotically lysed. Lytic effect of these antibiotics may lead to the depression of some bacterial autolysins synthesis which normally functions during cell division.
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