HAEMATOLOGICAL AND BIOCHEMICAL ALTERATIONS IN SHORT TERM EXPOSURE TO BISPHENOL A IN OREOCHROMIS MOSSAMBICUS (PETERS, 1852)K. ROY GEORGE, N.A. MALINI, G.S. PRAVEENA AND M.K. REJANIAbstract Effects of sub lethal concentration (1ppm) of bisphenol A (BPA) on the hematological and bio chemical parameters were studied in Oreochromis mossambicus on 7th and 21st day of exposure. Exposure to sub lethal levels of BPA elicited reduction in red blood cell (RBC) count, white blood cell (WBC) count and haemoglobin (Hb %), which can be attributed to the anemic condition caused by impaired haem synthesis. The bio chemical parameters like protein content and glycogen levels were decreased in response to impairment of protein synthesis and increased rate of glycolysis after BPA exposure. Alkaline phosphatase (ALK) and acid phosphatase (ACP) on the other hand were increased due to tissue damage caused by BPA. Increased rate of ammonia excretion in BPA exposed fish was resulted from the altered protein metabolism to overcome the stress conditions.
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