Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

ASSESSMENT OF SERUM LEVEL OF STROMAL DERIVED FACTOR – 1α (SDF – 1α) IN SERUM OF PATIENTS WITH SEPSIS AT ADMISSION AND DISCHARGE IN ALI – EBNE – ABITALEB HOSPITAL, RAFSANJAN AT 2014

ZIBA SHABANI, HAMID ABOUSAEEDI, GHOLAMHOSSIENHASANSHAHI AND MOHAMMAD KAMALI

Abstract

Sepsis is a major cause of death and the most common cause of death in the intensive care unit at a rate of 30 to 70 percent. SDF-1α as an ELR negetive CXC chemokine is effective in Cases of inflammatory cells in the blood and the role of chemokine activity by a process known as angiogenesis. This study compared the levels of these chemokines in patients with sepsis at admission and discharge based on age and gender studies. This study was performed in a cohort of 54 patients with sepsis who were admitted to the Hospital. The Peripheral blood sampling was performed (during admission and discharge) twice. Demographic data were collected through clinical history and methods. SDF-1α levels in the samples were measured. Results obtained along with demographic data using the software SPSS15, using T-test æ paired T-Test statistical analysis was performed. The 54 patients participating in the project, 41 were male (75.9%) and 13 females (24.07%) respectively. The minimum age of participants was 51 years and a maximum of 90 years in the project and the mean age was 69/13 years. The mean values of serum chemokines in patients with severe sepsis in the peripheral blood at the time of hospital discharge was significantly reduced and the differences were statistically significant (P <0.0001). Average concentrations at admission and discharge, respectively, were 222.780 and 58.980. Compared to the overall mean concentration of serum chemokines in patients with severe sepsis at admission by sex and age in peripheral blood concentrations were approximately equal in terms of differences not statistically significant (P =0.564, P =0.818). Compared to the overall mean concentration of serum chemokines in peripheral blood of patients with sepsis at the time of discharge based on sex, age and concentration was almost the same in terms of the differences was not statistically significant (P = 0.193 and P =0.816). Our study showed that the incidence of sepsis SDF-1α chemokine levels will increase significantly. Overall, the increase in concentration was not directly associated with age and sex. Finally, our study suggested that SDF-1α chemokine may be the early diagnosis and treatment of patients with sepsis and and perhaps other systemic inflammatory syndrome as a new treatment.