Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol. 17 Special Issue 2015; Page No.(109-116)

POLYMERIC NANO COMPOSITES AS DEXTEROUS DRUG CARRIERS IN STEERING UP BRAIN DRUG TARGETING: AN APPROACH TO COMBAT DEPRESSION

V. VIOLET DHAYABARAN, A. ANITA MARGRET AND T. NARGIS BEGUM

Abstract

Depression is the feeling of helplessness, hopelessness, and worthlessness and in the current global scenario people are stumbled by this menace which requires a stoppage solution. The study is devised in confronting depression under nanoscale by preparing nanocomposites which is a matrix of biopolymer chitosan that encapsulates the antidepressant drugs. Antidepressant drugs loaded nanocomposites with chitosan were prepared by the ionic gelation method. Both synthetic drug (Venlafaxine) and herbal formulations (St.John’s Wort and aqueous extract of Clitoria ternatea) were encapsulated. The contemporary study engrosses a joint inquiry of preparing nanocomposites with the crude aqueous leaf extract of the herb Clitoria ternatea in contrast with the commercial capsules of Hypericum perforatum (St. Johns wort) and skirmishing against depression by an in silico docking simulation study against monoamine oxidase. The prepared nano composite with the biopolymer chitosan enhances drug delivery and serves as a carrier. Nanocharacterisation studies like SEM and XRD analysis were performed to determine the morphology size and crystalinity. Thus this work aspires in developing a strategy against depression and emerging the potentials of Clitoria ternatea as drug in nano medicine.

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