Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol. 17 Special Issue 2015; Page No.(21-26)

A RESEARCH PERSPECTIVE ON EFFECT OF GREEN TEA EXTRACT IN PREVENTING AFLATOXIN INDUCED HEPATOCELLULAR CARCINOMA: APPLICATION OF NUTRITION, BIOINFORMATICS AND GENETICS IN THE FIELD OF FOOD TOXICOLOGY

SUBHASREE RAY AND RIFAT NAWAZ UL ISLAM

Abstract

The combined experimental and epidemiological evidence has led to designation of aflatoxins as human carcinogens according to International Agency for Cancer Research criteria. Mutation of p53 gene is found as a key factor in hepatocellular carcinoma (HCC), the most common form of liver cancer which is prominent in aflatoxin affected population. The site specific point mutation by Aflatoxin B1 (AFB1) generated epoxide, includes transversion of Guanine (G) to Thymine (T) in the 3rd position of 249 codon of p53 gene by producing highly mutagenic AFB1-FAPY adduct. According to experimental studies nutritional antioxidants like vitamin A, Vitamin C, Vitamin E, chlorophyllin and fermented probiotics are already proven to be effective in scavenging this highly negative epoxide molecule to prevent aflatoxin induced hepatic carcinogenicity. In this context our perspective study tries to see the scope of green tea polyphenolic compound Epigallocathechingallate (EGCG) as an antioxidant-anticancerous molecule for restricting tumor cell production and promotion in aflatoxicity by considering fundamental knowledge of Nutritional Science, Bioinformatics and Genetics. This biochemical and genetic analysis based study focuses on future perspective of genetic trait specific personalized recommended value of green tea extract which can be formulated, quantified and prescribed in the prevention of Aflatoxin induced HCC after evaluating all side effect possibilities of EGCG and other polyphenols. The perspective study thus concludes with a vision for a paradigm shift in disease prevention strategy based on consuming specific-purified phenolic compound containing green tea to strengthen the existing knowledge of Food toxicological research

Enter your contact information below to receive full paper.
Your Name :
Email:
Phone:
City:
Cost of Full Paper: Rs.75 for Indian Nationals or $20 (USD) for international subscribers.
By clicking on Request Paper you Agree to pay the above mentioned cost per paper.
  
Journal Issues
Vol 22, Issue 2, 2020
Vol 22, Issue 1, 2020
Vol 21, Issue 4, 2019
Vol 21, Nov. Suppl. Issue, 2019
Vol 21, Issue 3, 2019
Vol 21, Issue 2, 2019
Vol 21, Issue 1, 2019
Vol 20, Dec. Suppl. No.2, 2018
Vol 20, Issue 4, 2018
Vol 20, Dec. Suppl. Issue, 2018
Vol 20, Oct Suppl. Issue, 2018
Vol 20, Issue 3, 2018
Vol 20, Issue 2, 2018
Vol 20, Issue 1, 2018
Vol 20, Feb. Suppl. Issue, 2018
Vol 19, Issue 4, 2017
Vol 19, Nov. Suppl, Issue 2017
Vol 19, Issue 3, 2017
Vol 19, Issue 2, 2017
Vol 19, Issue 1, 2017
Vol 18, Issue 4, 2016
Vol 18, Issue 3, 2016
Vol 18, Issue 2, 2016
Vol 18, Issue 1, 2016
Vol 17, Issue 4, 2015
Vol 17, Issue 3, 2015
Vol. 17 Special Issue 2015
Vol 17, Issue 2, 2015
Vol 17, Issue 1, 2015
Vol 16, Issue 4, 2014
Vol 16, Issue 3, 2014
Vol 16, Issue 2, 2014
Vol 16, Issue 1, 2014
Vol 15, Issue 4, 2013
Vol 15, Issue 3, 2013
Vol 15, Issue 2, 2013
Vol 15 Issue 1, 2013
Vol 14, Issue 4, 2012
Vol 14, Issue 3, 2012
Vol 14, Issue 2, 2012
Vol.14, Issue 1, 2012
Vol.13, Issue 4, 2011
Vol.13, Issue 3, 2011
Vol.13, Issue 2, 2011
Vol.13, Issue 1, 2011
Vol.12, Issue 4, 2010
Vol.12, Issue 3, 2010
Vol.12, Issue 2, 2010
Vol.12, Issue 1, 2010
Vol 11, Issue 4, 2009
Vol 11, Issue 3, 2009
Vol 11, Issue 2, 2009
Vol 11, Issue 1, 2009
Vol 10, Issue 4, 2008
Vol 10, Issue 3, 2008
Vol 10, Issue 3, 2008
Vol 10, Issue 2, 2008
Vol 10, Issue 1, 2008
Vol 9, Issue 4, 2007
Vol 9, Issue 3, 2007
Vol 9, Issue 2, 2007
Vol 9, Issue 1, 2007
Vol 8, Issue 4, 2006
Vol 8, Issue 3, 2006
Vol 08, Issue 2, 2006
Vol 08, Issue 1, 2006
Vol 7 Issue 4, 2005
Vol 07, Issue 3, 2005
Vol 07, Issue 2, 2005
Vol 6 Issue 4, 2004
Vol 6 Issue 3, 2004
Vol 6 Issue 2, 2004
Vol 6 Issue 1, 2004
Vol 5 Issue 3, 2003
Vol 5 Issue 2, 2003
Vol 04, Issue 4, 2002
Vol 04, Issue 1, 2002
Vol 3 Issue 1-2, 2001
Vol 1 Issue 1-2, 2000
Vol 1 Issue 3-4, 1999
Vol 1 Issue 1-2, 1999
Looking for Past Issues? Click here to get them!!