CRUDE EXTRACT MULBERRY (MORUS ALBA L.) LEAVES CHLOROPHYLL IMPROVES URINE CREATININE LEVELS AND HISTOLOGY OF DIABETIC RAT KIDNEYNURMASARI SARTONO, DERY NOVIANTO, ERLANDY ULFA, A.B. SUSANTO AND RINI PUSPITANINGRUMAbstract - Urine creatinine levels could be used as an indicator of the body's energy metabolism. The aim of this research is to determine the effect of mulberry leaves crude extract (MLCE) doses (90 mg/Kg 150 mg/Kg of body weight, 120mg/kg 150 mg/kg of body weight, 150 mg/kg 150 mg/Kg of body weight) improves urinary creatinine levels and renal histology in streptozotocin-diabetic rats iduced (65 mg/Kg of body weight). Rats were randomly divided into five groups: control group 2 (positive and negative) and 3 groups; positive control (Glibenclamide 5 mg/Kg of body weight), negative control (streptozotocin -STZ), and groups of diabetic rats in 3 types MLCE doses given orally once daily for 14 days. Measurement of blood glucose levels on days 0,3,7,10, and 14 after induced by STZ. While the levels of urine creatinine and renal histology performed at the end of the experiment rats. The results of measurements of glucose levels in the blood (mg/dL) were tested for normality using the Kolmogorov- Smirnov test and Kruskal-Wallis. The results showed that MLCE did not lower blood glucose levels of diabetic rats. The results Showed no significance with urine creatinine levels in all treatments. At levels of 150 mg/Kg of body weight of MLCE (± 1.96 mg/dL) could be reduce the levels of urinary creatinine. Oral treatment of MLCE improve renal histology of diabetic rats.
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