INSULIN LEAVES (SMALLANTHUS SONCHIFOLIUS) DRY EXTRACT IMPROVES BLOOD GLUCOSE AND LIPID PROFILE IN ALOXAN-INDUCED RATFLORI R. SARI1, HARI HENDARTO, ANNISATUL MUQORROBIN, CANDRA AHMAD H.R., ELZA AMELIA, HERMANSYAH, LARAS RESPATI3 AND NURMA MAULIDAAbstract Insulin leaves (Smallanthus sonchifolius) have been traditionally used in South America as an anti-hyperglycemic agent, however, the dose, the usage and the duration of these leaves as an anti hyperglycemic agent is unclear. This work intends to elucidate the impact of insulin leaves dry extract on blood glucose and lipid profile in aloxan-induced rat. Insulin leaves were extracted as dry extract. Aloxan-induced Sprague-Dawley rat were given 300 mg/kg BW insulin leaves dry extract once daily for 14 days. Blood glucose level and body weight were evaluated weekly. Cholesterol level and tryglyceride level were analyzed at the end of the study. Aloxan injection induced hyperglycemic condition in the rat, mimicking diabetic condition. Daily decoction of insulin leaves dry extract for 14 days significantly reduced blood glucose level in aloxan-induced rats. Additionally, cholesterol and tryglyceride level were increased in aloxan-induced rats and daily decoction of insulin leaves dry extract for 14 days significantly reduced these levels. Fourteen days daily decoction of 300 mg/kg BW insulin leaves dry extract improved blood glucose and lipid profile in diabetic rat, suggesting the further potential of insulin leaves as diabetic drug.
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