MAJOR AND MINOR PROTEASE INHIBITOR RESISTANCE MUTATIONS ARE FREQUENT IN HUMAN IMMUNODEFICIENCY VIRUS-1 CRF39_BF AND CRF40_BFPRASETYO A.A. AND SARIYATUN R.
This study was aimed to find out the status of major and minor PI resistance-associated mutations in HIV-1 subtypes and CRFs (Circulating Recombinant Forms). HIV-1 sequences containing protease region available in the Los Alamos HIV-1 database (n= 3,179) were analyzed for major/minor PI resistance-associated mutations and viral tropism. The major PI resistance-associated mutations was frequent in CRF04_cpx (44.4%), CRF23_BG (50.0%), CRF28_BF (20.0%), CRF38_BF (20.0%), CRF39_BF (100%), CRF40_BF (50.0%), and CRF46_BF (25.0%), whereas minor PI resistance-associated mutations was frequently found in subtype J (25.0%), CRF04_cpx (22.2%), CRF10_CD (66.7%), CRF15_01B (20.0%), CRF28_BF (20.0%), CRF37_cpx (66.7%), CF38_BF (20.0%), CRF39_BF (100%), CRF40_BF (50.0%), and CRF44_BF (50.0%), as well as HIV-1 group N (100%), O (100%), and P (100%). All X4 strains were found to contain major PI resistance-associated mutations. The results of the present study contribute information about the status of major/minor PI resistance-associated mutations and tropism among HIV-1 subtypes and CRFs.
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