Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 16, Issue 2, 2014; Page No.(445-448)

MOLECULAR DOCKING STUDIES ON TRANSPOSASE PROTEIN OF STREPTOCOCCUS PNEUMONIAE- TCH8431/19A STRAIN

BALASANKAR KARAVADI AND M. XAVIER SURESH

Abstract

Streptococcus pneumoniae causes mucosal diseases in human upper respiratory tract. TCH8431/19A strain of Streptococcus pneumoniae is extremely virulent in pneumococcal pathogenesis which contains Protein coding gene (HMPREF0837_11199) which synthesizes transposase protein. In this article we performed the homology modeling studies of the virulent protein which is synthesized by the protein coding gene and validated the nature of the receptor as a future drug target for TCH8431/19A strain of Streptococcus pneumoniae. We have also identified specific ligands for the above mentioned protein by using the virtual structure based ligand screening approach. Protein-ligand complexes have been analyzed by docking studies using Discovery Studio and interactions have also been visualized along with the validation of pharmacokinetic descriptors.

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