Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 15, Issue 4, 2013; Page No.(627-638)

WOUND HEALING ACTIVITY OF COLEUS AROMATICUSIN EXPERIMENTALLY INDUCED DIABETIC MICE

KALESWARE MUNIANDY, ZAITON HASSAN AND MOHD HAFEZ MOHD ISA

Abstract

Background. The ethanolic and aqueous extract of C.aromaticusleaves and roots (100 mg kg -1 day -1 for 10 days) were evaluated for its wound healing activity in Monosodium Glutamate induced diabetic mice using excision and dead space wound models. Excision wound model was performed on five different groups of mice to measure the progress of wound area for ten consecutive days. Dead space wound model was performed on four different groups of mice to estimate wet and dry granulation tissue as well as to examine the histological appearances of granulation tissue after ten days. Ethanolic extract treated wounds was found to show 76.6% of wound area reduction when it is compared with controls that exhibited 55.9 % of wound area reduction. The ethanolic extract treated wound had epithelised faster compared to controls. The wet and dry granulation tissue weight has increased significantly in extract treated mice when it is compared with the controls. Extract treated mice exhibited good proliferation of collagen tissue with satisfactory angiogenesis. Coleus aromaticus promotes significant wound healing in induced diabetic mice and evaluation of this activity on human organism is highly suggested.

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