GENETIC POLYMORPHISM OF THE GLUTATHIONE S-TRANSFERASE ML, T1 AND DEVELOPMENT OF BREAST CANCERS. SUDHA, SASIKALA, B. KR1SHNAVENI AND R. SANGEETHA
Glutathione S- Transferase (GST) genes are involved in the metabolism of various carcinogens. Previous studies indicated that absence of GSTM1 and Ti enzyme correlates with an increased risk in developing certain type of cancers. In the present study, the associations between genetic polymorphism in the GSTM1 and GSTT1 genes were investigated, in relation to breast cancer risk in 78 breast cancer patients and 100 controls. The frequency of the GSTM1 genotype in control and breast cancer groups were 52%, 71.79% whereas 48% controls, 28.21% breast cancer cases had the GSM1 null genotype. The genotypic distribution of GSTT1 was 59% in controls and 67.95% in breast cancer cases and GSTT 1 null genotype was 32.05% in controls and 41% in breast cancer cases. Statistical analysis indicates that there is no association of the GSTM1 and GSTT1 polymorphism and hence the gene does not appear to play a significant role in the development of breast cancer.
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