CLINICAL AND BIOCHEMICAL EVALUATION OF BLOOD SERUM ENZYMES IN OSTEOFLUOROSISA. SHASHI AND MANISH KUMARAbstract A case control study was undertaken among individuals residing in a fluoride affected area in Punjab, India. The patients of skeletal fluorosis were examined and compared with 24 age-matched controls for their serum enzymes activities of creatine kinase (CK), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH) and alpha-amylase. The activity of CK and GGT was elevated significantly (p<0.001) in all age groups as compared to controls. The levels of serum LDH activities in all age groups were higher than in the controls but only the differences for age groups 20-40 and 70-80 years were statistically significant (p<0.05-0.001) The patients of skeletal fluorosis showed non-significant differences in the activity of alpha-amylase in comparison controls subjects in all age groups except in 40-50 years, where a significant (p<0.001) increase occurred.
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