OPTIMIZATION OF ANTIBIOTIC COMPOUND PRODUCED BY STREPTOMYCES SP. ISOLATED FROM EARTHWORM GUT (EISENIA FOETIDA).S. ARUNA, K. VIJAYALAKSHMI, M. SHASHIKANTH, M. SUREKHA RANI, K. JYOTHIl, N.D. PRASANNA, S.K. SHASHEEN AND K. PAVANA IYOTSNA
Screening was performed to detect the antimicribiol activity exhibiting Actinomycetes from earthworm gut. Twenty tined a n.:.1 among them 9 isolates showed good activity. AS1 isolate showed higher activity -vvi7f-m cornrcu.ed to other strains. Influence of different media, carbon and nitrogen sources and different pllysical parameters like temperature, pH and NaC1 concentration, effect of incubation period on antibiotic production was studied. Optimum conditions for maximum production of compound were deduced from the studies. Based on morphological and biochemical characteristics the isolate AS1 was detected to be Streptonty ces sp., having broad-spectrum antagonistic activity against a wide range of pathogenic and plant pathogenic bacteria and phytopathogenic fungi.
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