EFFECT OF DEXAMETHASONE ON THE CAPRINE ANTIGEN PRESENTING CELLS FUNCTIONM. ANANDA CHITRA AND G. C. RAM
Functional efficiency of caprine macrophages and B cells, and the effect of dexamethasone on their function were studied in the present investigation. Macrophages induced more proliferation in unprimed animals whereas B cells stimulated significantly (p<0.01) increased proliferation of T cells in sensitized animals, indicating the specific and memory response, characteristics of adaptive immune system. S.aureus induced more proliferation followed by aparattiberculosis and tetanus toxoid. Autologous macrophages and B cells were used as target cells to assess the cytotoxicity by MTT colorimetric method. M. paratuberculosis primed macrophages and B cells were subjected to cytotoxicity more than S.aureus and TT primed macrophages and B cells. Dexamethasone did not influence on the antigen presentation and cytotoxicity function of caprine macrophages and B cells. Caprines may be considered as corticosteroid resistant species.
Enter your contact information below to receive full paper.