BIOCHEMICAL CHARACTERIZATIONS OF FEW MEDICINAL PLANTS WITH REFERENCE TO ANTIFIBRINOLYTIC ACTIVITYG. RENUGA
An attempt was made to understand the effect of plant extract on fibrinlytic properties. Three plants were selected plants such as Garlic, Onion, and Ocimum sps and screened for their efficiency in solubilized blood clot. Extracts of selected plants were compared to identify the principle component has efficiency in solubilized blood clot. 1Based on this properties garlic extract has been identified as right plant extract which can be used for further experimental studies, which has high efficiency in solubilized blood clot. The garlic extract has active principle component behind such effects could be isolated through the usual separation techniques and characterized. The component identified from garlic extract has antiplatelet action and its effect has been studied by administration of these extract into hypertrophy induced rat model. Cardiac hypertrophy has been monitored heart wt/body wt ratio at different intervals after aortic constriction along with oral administration of garlic extract in rat. Increased levels of marker enzymes such as CPK, LDH and SCOT in the operated animals, showing a slight reduced activity upon garlic extract administrated levels again strengthen the view that the garlic extract may reduce the hypertrophy damage that occur in the operated (hypertrophy induced) animals. The score of necrosis and inflammation correlated with the decrease in severity of hypertrophy when treated with extract was observed by histopathological examination.
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