Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 10, Issue 2, 2008; Page No.(333-336 )

PHYTOCHEMICAL AND ANTI-INFLAMMATORY STUDIES OF OLDENLANDIA LIMBELLATA

SANTH RANI THAAKUR, E. MAHESWARI, G.R. SARASWATHY, V. HEMA, V. REKHA, Y. PRAPURNA CHANDRA, V. KISHANLAL AND K. BHANU PRASAD

Abstract

Olden landia urnbellata (Rubiaceae) is commonly found in the regions of India, Burma, Sri Lanka, Cambodia and Indonesia. This plant is used in the treatment of asthma and bronchitis. Ethanolic extract of whole plant of Oldenlandia umbellata was screened for anti-inflammatory activity in carrageenan induced rat paw oedema at the dose levels of 100, 200 and 400mg/kg was compared with the standard drug, Diclofenac Sodium. The extract produced significant and dose dependent inhibition of carrageenan induced paw edema. The results were found to be significant (P<0.05) when compared to control. Preliminary phytochemical analysis of Oldenlandia umbellata indicated the presence of alkaloids and glycosides. Further studies may reveal the exact mechanism of action and phytochemical constituents responsible for the anti-inflammatory activity.

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