Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 6 Issue 2, 2004; Page No.(313-375 )

BIOTRANSFORMATION OF AMOXYCILLIN

S. MAZUMDAR, R.K. SAMANTA AND M.K. ROY

Abstract

Upon incubation of amoxycillin and resting cells of Bacillus sp. MXI in 25mM tris HCl, pH 7.0 and subsequent determination of antibacterial activity of the supernatant obtained after separation of cell mass revealed that it was antibiotically active aAainst amoxycill in resistant Bacillus stearotherrnophilus. Thin layer chromatographic analysis of the supernatant revealed the presence of a compound (Rf 0.36) which is different from amoxycillin (Rf 0.5). UV spectrum of the compound eluted from TLC plate was also different from that of amoxycillin and shows antibiotic activity suggesting the possible transformation of amoxycillin to other compounds with improved antibacterial activity. The identity of the compound formed does not match with probable betalactams and therefore has accumulated after transformation.

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